Motivoice
Member
Hey guys,
I’d appreciate some input from people who actually understand the pharmacology behind these compounds.
I’ve been on 200 mg testosterone for about 10 weeks, and I started dutasteride at the same time (0.5 mg, 3–5x per week). I also added 5% topical minoxidil about 3–4 weeks ago and use ketoconazole shampoo once weekly.
My main concern is this:
Since dutasteride only blocks DHT, could testosterone itself still meaningfully drive miniaturization? If so, would adding a topical androgen receptor antagonist like RU58841, pyrilutamide (KX-826), or PP405 meaningfully reduce that risk?
At the same time, I’m concerned about systemic absorption. If RU or pyrilutamide go systemic, they would theoretically block androgen receptors more broadly, including testosterone signaling. That could potentially have more systemic consequences than DHT suppression alone.
Are there any actual human pharmacokinetic data showing how much RU or pyrilutamide go systemic? Or are we mostly extrapolating from molecular weight and animal data?
Also, I’m trying to understand when to actually “pull a lever” instead of stacking compounds out of fear.
For example:
At what point would increasing dutasteride dose make sense?
When would switching to finasteride be rational?
When would adding RU or pyrilutamide actually be justified?
When would lowering testosterone dose be the logical move?
Is the typical progression pattern something like: 3–6 months shedding → 3–6 months regrowth → repeat cycles with gradual improvement?
Or is that overly simplified?
I’m trying to approach this rationally instead of reacting emotionally to short-term shedding.
Any evidence-based input is appreciated.
Greetings
Thanks.
Quick Addition i forgot :
In about 4 weeks I’ll be getting a full blood panel including thyroid (TSH, fT3, fT4, antibodies), total T, free T, SHBG, DHT, E2, prolactin, etc.
Given that my mother had hypothyroidism and I’ve had some temperature regulation issues, I’m wondering:
How much of a realistic factor is thyroid dysfunction in hair density changes or increased shedding — especially in someone already manipulating androgens?
I understand thyroid issues don’t cause classic androgenetic alopecia, but could they exacerbate shedding or make follicles more vulnerable?
Also, once I get my bloodwork back, what would be the best way to follow up here without reopening the whole discussion from scratch? Should I reply in this thread with values for context?
Appreciate any insight
I’d appreciate some input from people who actually understand the pharmacology behind these compounds.
I’ve been on 200 mg testosterone for about 10 weeks, and I started dutasteride at the same time (0.5 mg, 3–5x per week). I also added 5% topical minoxidil about 3–4 weeks ago and use ketoconazole shampoo once weekly.
My main concern is this:
Since dutasteride only blocks DHT, could testosterone itself still meaningfully drive miniaturization? If so, would adding a topical androgen receptor antagonist like RU58841, pyrilutamide (KX-826), or PP405 meaningfully reduce that risk?
At the same time, I’m concerned about systemic absorption. If RU or pyrilutamide go systemic, they would theoretically block androgen receptors more broadly, including testosterone signaling. That could potentially have more systemic consequences than DHT suppression alone.
Are there any actual human pharmacokinetic data showing how much RU or pyrilutamide go systemic? Or are we mostly extrapolating from molecular weight and animal data?
Also, I’m trying to understand when to actually “pull a lever” instead of stacking compounds out of fear.
For example:
At what point would increasing dutasteride dose make sense?
When would switching to finasteride be rational?
When would adding RU or pyrilutamide actually be justified?
When would lowering testosterone dose be the logical move?
Is the typical progression pattern something like: 3–6 months shedding → 3–6 months regrowth → repeat cycles with gradual improvement?
Or is that overly simplified?
I’m trying to approach this rationally instead of reacting emotionally to short-term shedding.
Any evidence-based input is appreciated.
Greetings
Thanks.
Quick Addition i forgot :
In about 4 weeks I’ll be getting a full blood panel including thyroid (TSH, fT3, fT4, antibodies), total T, free T, SHBG, DHT, E2, prolactin, etc.
Given that my mother had hypothyroidism and I’ve had some temperature regulation issues, I’m wondering:
How much of a realistic factor is thyroid dysfunction in hair density changes or increased shedding — especially in someone already manipulating androgens?
I understand thyroid issues don’t cause classic androgenetic alopecia, but could they exacerbate shedding or make follicles more vulnerable?
Also, once I get my bloodwork back, what would be the best way to follow up here without reopening the whole discussion from scratch? Should I reply in this thread with values for context?
Appreciate any insight
